TAFLIKHAH ULIN NUHA, 020911107 (2013) APLIKASI SERBUK NATURAL HIDROKSIAPATIT-CHITOSAN TERHADAP PROLIFERASI MAKROFAG PADA PERBAIKAN JARINGAN TULANG. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Periodontal disease happens approximately at 10% of adult populations, characterized by loss of attachment beetwen tooth and bone, resulting in bone resorbtion and eventually bone loss. In the wound healing process to repair bone tissue, macrophage have an important role. To facilitate the healing process, bone graft is placed in the bone defect. Compounding hydroxyapatite-chitosan can result in better osteoconductivity properties and scaffold strength than both of material stands alone. Purpose. The aim of this study was toknow the effect of hydroxyapatite-chitosan aplication on macrophage proliferation in bone remodelling. Method. This research was done in vivo experiment by created a defect on rabbit’s tibiae. 20 rabbits were divide into 4 groups The 1st group treated with 70:30 hydroxyapatite-chitosan powder, examined after 4 days. 2nd treated with 30:70 hydroxyapatite-chitosan powder, examined after 4 days, 3th group treated with 70:30 hydroxyapatite-chitosan powder, examined after 7 days and 3th group treated with 30:70 hydroxyapatite-chitosan powder, examined after 7 days. Macrophages were observed and accounted under light microscope and outcome data were analyzed using statistical One-way Anova. Results. There were significant differences in the number of macrophage among groups. There were significant differences in the number of macrophage between two groups treated with 70:30 hydroxyapatite-chitosan powder at days 4th and 7th. Conclusion. In bone remodelling, Hydroxyapatite-Chitosan 70:30 graft powder better in controlling the proliferation of macrophages ( in inflammatory and proliferative phase) than Hydroxyapatite-Chitosan 30:70 graft powder.

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