Arif Mamba'ul Ilmi Zulfitri, 020911108 (2013) EFEK GEL EKSTRAK DAUN BINAHONG (Anredera Cordifolia) TERHADAP JUMLAH SEL FIBROBLAS DAN PEMBULUH DARAH KAPILER PADA LUKA PASCA PENCABUTAN GIGI MARMUT (Cavia Cobaya). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background: Tooth extraction are everyday actions performed by a dentist that needed wound healing treatment. Binahong is a known one of medical plant that is easy to grow in any condition. Binahong (Anredera Cordifolia) contains useful substances like quercetin (flavonoid) and terpenoid, which are belived to act as antioxidant and take part in wound healing process. Purpose: To know the effect of extract Binahong leaf gel towards fibroblast cell and capillary of Cavia cobaya over wound healing process after tooth extraction. Methods: The research sample consisted of 28 male guinea-pigs, have their left incisive tooth extracted and then divided into 4 groups based on concentrations: 0%, 20%, 40%, and 80%. Samples are executed on the 4th day of application to perform histopathological evaluation as well as to count fibroblast cell and capilarry among groups. Result: This research has proven the increased growth of fibroblast cell and capillary on application of Binahong leaf gel. The result showed there was significant difference in fibroblast cell and capillary amount between treatment group and control(p<0,05). The higher the doses, the more capillary and cell growth. Conclusion: Application of Binahong leaf extract gel (Anredera cordifolia) between the treatment group with a control group has been proven to increase the amount of fibroblasts cell and capillary blood vessels in the wound after tooth extraction guinea pig (Cavia cobaya).

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