RAHMA AULIA LESTARI, 020911093 (2013) PERAN FLAVONOID DAN CAPE DALAM PROPOLIS TERHADAP INDUKSI FmROPLASIA DAN EPITELISASI PADA PENYEMBUHAN LUKA PASCA EKSTRAKSI GIGI (Penelitian Eksperimenta1 Laboratoris). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Tooth extraction is the most common treatment ill dentistl~y. There are mOlIV complications in post extraction wound. One of the preventive Ireatment is llsing topical agents such as propolis. Propolis is a bee product that used os wound healing therapv. Propolis contains flavonoids and CAPE that can enhance fibropll/sia and epithelializatio/l in post-extraxction wound. Purposes: The aims of this stud.v well' sfud.ving .fibroplasia and epithelization during post extraction wound healing using .tiav(lnoids and CAPE in rats. Methods: This research used 32 Whistar rats divided into 2 groups, control group (K) and treated group (P), each group was divided into 2 sub-groups hased on time of samples coUeting. Central lejt incisors on each group extracted then pos/ ('.·traction V!)()und in group P was treated by 10% propolis gel-with active ingredientflavonoid and CAPE v-,'hile in grollp K was treated by 100% gel. The rats were sacrified at 3'd and days (lfler extructioll. The fibroplasia and epithelizations are showed by counted amount ,}ffibroblas and epithelial layers from HPA preparations mandibular biopsy results. Result..·: ]0% propolis gel I1Uh active ingredients flavonoid and CAPE couldn 'f increase amow/I offibrobl£lst signilicalllir (p>O.05). But, it could increase amount of epi/iJelial layers (p<()J)5). Conclusion: f(J(:~) propolis gel with active ingredients .flavonoid and CAPE could illcrease proliferation phose oj'post extraction wound healing, especially on collagen maturatj,m andfibrocytefbrma/ioJ7. But, it has no significant effect on fibroblas formation. Epitheliolization increase is I1Wr/il'd by increas amount ofepithelial layers and epithelial vl'ound cl(Jc)'ur,

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