TEGAR PERMADI D. P., 021011020 (2014) BIOKOMPATIBILITAS EKSTRAK DAUN SIRIH MERAH (Piper crocatum) DANCHLORHEXIDINE GLUCONAT0,2% TERHADAPSEL FIBROBLAS BHK-21. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background.Piper crocatum is one of potential herbal plant which is well known as medicaments. The leaf of piper crocatum have antiinflamatorry and wound healing effect. It hasgood biocompatibility and is not toxic, and it is expected to replace the use of irrigation such as 0,2% chlorhexidine gluconat as material in dentistry. Purpose.The aim of this study is to determine the biocompatibility of Piper crocatum with different concentration against 0,2% chlorhexidine gluconattoward BHK-21 fibroblast cells. Method.This research is laboratory experimental with the post-test control group design. Piper crocatum was extracted using ethanol and then was diluted with Eagles media into concentration 100%, 50%, 25%, 12,5%, and 6,25%. Biocompatibility was observed after 24 hours using MTT assay technique, observed by ELISA reader. Result. The result showed that the percentage of proliferation cell of Piper crocatum leaf extract with concentration 100%, 50%, 25%, 12,5%, and 6,25% were 58.15%, 24%, 11.60%, 12.02%, 8.90%, and the resultof0,2% chlorhexidine gluconat was 5.24%. Conclusion. Piper crocatum in some concentration are more biocompatible than 0,2% chlorhexidine gluconat toward BHK-21 fibroblast cell.

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