Monika Werdiningsih (2015) Uji Biokompatibilitas Tanin Ekstrak Kulit Manggis (Garcinia Mangostana Linn.) 0,78% Dan Chlorhexidine Gluconate 0,2% Terhadap Kultur Sel Fibroblas Bhk-21. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background. Chlorhexidine gluconate is one of endodontic irrigants potential due to its antibacterial activity. Although it is an effective antibacterial agent, chlorhexidine gluconate can not dissolve organic substances and necrotic tissue present in the root canal. In addition, same as other chemicals, chlorhexidine gluconate also cause a cytotoxic effect. Tannin extracts of mangosteen pericarp (Garcinia mangostana L.) demonstrated various biological activities including antibacterial, antioxidant, anticancer and anti-inflammatory. Tannin extracts of mangosteen pericarp can be considered as an alternative endodontic irrigation for dental application. Purpose. The aim of this study was to compare the biocompatibility between 0,78% tannin extracts of mangosteen pericarp and 0,2% chlorhexidine gluconate to BHK-21 fibroblasts cell. Method. Tannins obtained from extracts of mangosteen pericarp. Preliminary test by testing the biocompatibility of tannin extracts of mangosteen pericarp in various concentrations of the BHK-21 fibroblasts. Tannins extracts of mangosteen pericarp at concentrations of 0,78% less toxic than the other concentrations. Then biocompatibility of 0,78% tannin extracts of mangosteen pericarp compare with 0.2% chlorhexidine gluconate using cytotoxicity test on BHK-21 fibroblasts cells with MTT method and observed by ELISA reader. Results. 0,78% tannins extracts of mangosteen pericarp showed good biocompatibility with fibroblasts BHK-21 than 0,2% chlorhexidine gluconate. There is a significant differences between the results of treatment with 0,78% tannin extracts of mangosteen pericarp and 0.2% chlorhexidine gluconate. Conclusion. 0,78% tannin extracts of mangosteen pericarp has better biocompatibility than 0,2% chlorhexidine gluconate as an endodontic irrigants.

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