Chaterina Puspadewanti Rinaldhi (2015) Efek Ekstrak Buah Pare (Momordica charantia Linn.) Terhadap Jumlah Sel Leydig Tikus Putih (Rattus norvegicus) Hiperglikemia. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The aim of this research was to find out the effect of bitter melon (Momordica charantia Linn.) extracts in the amount of Leydig cells hyperglycemic white rats (Rattus norvegicus). This research used 24 white rats are 2-3 months old which has 180-200 g of body weight. They were devided randomly into 6 groups. Alloxan induced pancreatic damage was performed in 5 groups with 150 mg/kg body weight intraperitoneally. After state hyperglycemic condition, 3 groups was treatment with a dose therapy of bitter mellon (Momordica charantia Linn.) extracts, (P1) 29mg/ml/day, (P2) 50 mg/ml/day, and (P3) 59 mg/ml/day, one group as a control negative was given CMC Na 0.5% 1ml/day, one group as a control positive was given Glibenclamide® 0.126 mg/ml/day. One group as a control normal was induced CMC Na 0.5% 1ml/day without alloxan 150 mg/kg body weight intraperitoneally. After 14 days treatment, 24 white rats were killed and harvest the testes to made a histopathology preparations using Haematoxylin Eosin (HE) staining. The data were analyzed by Analysis of Variance (ANOVA) method based on Completely Randomized Design, and further analyzed by Duncan’s multiple range. The treatment (P3) 59 mg/ml/day dose can increase the amount of the highest Leydig cells compared with P1 and P2 groups (29mg/ml/day and 50 mg/ml/day). The results from statistical analysis showed that treatment with bitter melon (Momordica charantia Linn.) extracts 50 mg/ml/day dose increased the amount of Leydig cells (42.80 ± 4.55) of hyperglycemic white rats (p < 0.05).

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