Gavrila Amadea Puspitarani (2015) Effect Of L-Arginine On The Thickness Iliac Arteries Wall Post Surgical Embolectomy With Fogarty Balloon Catheter In Rabbit (Oryctolagus cuniculus). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The effect of the chronic administration of L-arginine on iliac arteries thickness after surgical embolectomy were examined. Sixteen New Zealand White male rabbits underwent unilateral iliac artery surgical embolectomy using Fogarty balloon catheter. Then the animals were divided into two group of control (P0) fed with standard rabbit diet and treatment (P1) standard rabbit diet added with L- arginine in their drinking water 4 for weeks. The iliac arteries were harvested for histological slide preparation with routine method and data were analyzed by independent T-test. The vessel thickness was significantly decreased on the P1 (234.1± 18.1 µm) than P0 (411.6 ± 191.7 µm). Furthermore, the thickness of intimal was significantly decrease in P1 (140.9± 27.0 µm) compared with P0 (304.3± 215.7 µm). As a result, there was no significant different on the thickness of medial between P1 (93.2± 15.7 µm) and P0 (107.3± 101.5 µm). The results demonstrate that L-arginine decreased iliac artery wall thickness after surgical embolectomy with Fogarty balloon catheter in rabbit.

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