Ni Komang Aprilina Widi Suputri (2015) Pengaruh Pemberian Ekstrak Bawang Merah (Allium ascalonicum L) Terhadap Gambaran Histopatologi Hepar Tikus Putih (Rattus norvegicus) Yang Diinduksi Aloksan. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This study was aimed to know the effect of giving shallot extract (Allium ascalonicum L) to histopathological feature of rat (Rattus norvegicus) liver induced by alloxan. Alloxan were intraperitoneally injected 120 mg/KgBW (single dose). A total of twenty male wistar rats of three months old were used in study. The rats were devided into five groups. 1) negative control group (K-) treated by CMC Na 0.5 %, 2) positive control group (K+) treated by metformin 45 mg/KgBW as a standard drug, 3) extract of Allium ascalonicum 250 mg/KgBW (P1), 4) extract of Allium ascalonicum 500 mg/KgBW (P2), 5) extract of Allium ascalonicum 750 mg/KgBW (P3). Rats were treated for 14 days. The data of this study were analyze by Kruskal Wallis Test, then it continued by Mann-Whitney Test. The result of this study is Allium ascalonicum can improve histopathological feature of rats liver incuced by alloxan.

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