Christina Mariantje Natal, 060710344 (2012) EFEK EKSTRAK RIMPANG KUNYIT PUTIH (Curcuma zedoaria) TERHADAP ANGIOGENESIS PADA MEMBRAN KORIOALANTOIS TELUR AYAM BEREMBRIO. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Angiogenesis is the most important stage in cancer development. In the presence of angiogenesis, cancer cells can develop and destroy specific tissues and can metastasize to other tissues. Inhibition of angiogenesis is the right solution for treating cancer. Curcumin which are concentrated in the extract of white turmeric (Curcuma zedoaria), widely known has antiangiogenic effect. The study was aim to investigate antiangiogenic effect of white turmeric by counting the number of new blood vessels based on haematoxylin-eosin staining. Eggs at the age of nine days were divided into 6 groups. Two groups are control: bFGF and vehicle. The next four groups are extract of white turmeric that variate in 4 dossage: 60, 75, 90 and 110 μg. At the age of twelve, the shell was opened and chorioallantoic membranes were collected for histopathologycal preparation. Based on haematoxylin-eosin staining, angiogenic blood vessel in the extract group was less than the control bFGF group. The results show that the extract of white turmeric could inhibit angiogenesis.

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