Annisa Mutmainnah, 060810232 (2013) PENGARUH PEMBERIAN EKSTRAK DAUN SIRIH MERAH (Piper crocatum) TERHADAP GAMBARAN HISTOPATOLOGI LUKA INSISI KULIT TIKUS PUTIH YANG TERINFEKSI Staphylococcus aureus. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The aim of this research is to know the effect of red betel leaf’s extract (Piper crocatum) to the histopatology image in wistar rat’s skin which infected by Staphylococcus aureus. The experimental laboratoric research use Randomized Post Test. It was designed for 20 wistar male rats, in 3 month ages and divided into 5 group, P0 was negative control group wound without medical treatment, P1 was positive control group wound with Povidone iodine, P2 was group wound with red betel leaf’s extract 50%, P3 was group wound with red betel leaf’s extract 25% and P4 was group wound with red betel leaf’s extract 12,5%. Hypothesis test such as total of neutrophil, macrophage, fibroblast, and angiogenesis were analyzed by ANOVA and LSD. Whereas collagen density was analyzed by Kruskall-Wallis test and Mann-Whitney test. The result of this research was P4 group (group wound with red betel leaf’s extract 12,5%) can improve the histopotology image in rat’s skin which infected by Staphylococcus aureus.

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