Werstant Adhityananda Rinaldhi (2015) Potensi Propolis Terhadap Jumlah Limfoblas Dan Diameter Pulpa Putih Limpa Mencit Jantan (Mus Musculus). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The aim of this research was to find out the effect of propolis in the amount of lymphoblast cells and the correlation between the treatment of propolis with spleen diameter each of white male mice (Mus musculus). This research used 25 male white mice which are 12 weeks old which has 25-35 g of body weight. They were devided randomly into five groups. (P0) as a control was given 0.5 ml aquades/day, and other group were given propolis for (P1) 0.4mg/0.5ml/day, (P2) 0.8mg/0.5ml/day, (P3) 1.6mg/0.5ml/day and (P4) 3.2mg/0.5ml/day. After a two week treatment, 25 mice were sacrificed their spleen were taken then used in histological preparation with H.E staining. The data were analyzed by ANOVA method based on Completely Randomized Design, and further analyzed by Duncan's multiple range (Duncan's Multiple Range Test). The result from statistical analysis showed that treatment with propolis increased the amount of lymphoblast cells also the spleen diameter of white male mice (p<0.05). The best dose is 0.8mg/0.5ml/day which show positive correlation amount of lymphoblast and white pulp spleen diameter. Keyword: Propolis, lymphoblast, white pulp, spleen

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