VIANINTA GEOTIVANNY, 060810129 (2012) PENGARUH PEMBERIAN BORAKS (Na2B4O710H2O) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS PUTIH (Rattus norvegicus). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The purpose of this study was to evaluate the changes of kidney histopathology after giving borax on wistar rats using different dose. The research has been done on February, 6th 2012-March, 8th 2012 at Mulyorejo Utara street number 51A Surabaya and Faculty of Veterinary Medicine, Airlangga University. 20 male rats (Rattus norvegicus strain wistar) aged 45 days with BW 100 g were used. The rats devided into five groups; rats in one groups was only given sterile aquadest 0,5 ml/rats/day per oral, second groups was given with borax 26 mg/rats/day per oral, third groups was given with borax 52 mg/rats/day per oral, fourth groups was given with borax 78 mg/rats/day per oral and the last groups was given with higher dose of borax was 104 mg/rats/day per oral. The data were compared using Kruskal-Wallis test. Statistical comparisons were performed using SPSS 18.0 for windows. This research showed that borax can cause abnormalities on kidney histopathology on rats such as haemoraghic, degeneration and necrosis cell because (p < 0,05).

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