YULIA SARI ISMAIL, 090610041D (2012) ANALISIS SUBTIPE HIV DAN STADIUM KLINIS PENYAKIT HIV/AIDS DI JAWA TIMUR. Disertasi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Human Immunodeficiency Virus type 1 (HIV-1) known to cause Acquired Immune Deficiency Syndrome (AIDS) are divided into several subtypes (A, B, C, D, F, G, H, J, K) and Circulating Recombinant Form (CRF). Different characteristics of subtype of the virus and its interaction with host can affect the severity of the disease. The aims of this study was to analyze HIV-1 subtypes circulating in HIV/AIDS patients from the East Java region and to analyze its relationship with clinical stage of HIV/AIDS. Blood plasma from the patients who came to the Intermediate Care Unit of Infectious Disease (UPIPI) Dr. Soetomo Hospital Surabaya from various area representing the East Java regions who tested to be HIV positive was used. HIV gp120 env gene region was amplified by using specific primer and then the PCR product was purified, sequenced and analized its homology and phylogenetic. It was found that the most dominant subtype in East Java was in one group of Circulating Recombinant Form (CRF) that are CRF01_AE, CRF33_01B, and CRF34_01B. In the the phylogenetic tree was done by neighbour-joining method, the result were most of HIV samples (30 samples) were in the same branch with CRF group, except one sample (HIV40) was in the same branch with subtype B group. HIV subtypes was not significantly associated with clinical stage where samples from different stages of HIV/AIDS have the same HIV subtypes.

Item Type:	Thesis (Disertasi)
Additional Information:	KKA KK Dis. K. 47/13 Ism a
Uncontrolled Keywords:	HIV/AIDS, phylogenetic analysis, subtype, clinical stage.
Subjects:	K Law > K Law (General) > K1-7720 Law in general. Comparative and uniform law. Jurisprudence > K(520)-5582 Comparative law. International uniform law > K3566-3578 Public health R Medicine > RA Public aspects of medicine
Divisions:	09. Sekolah Pasca Sarjana > Ilmu Kedokteran
Creators:	Creators NIM YULIA SARI ISMAIL, 090610041D UNSPECIFIED
Contributors:	Contribution Name NIDN / NIDK Thesis advisor Soetjipto, Prof.,dr.,MS.,Sp.MK(K) UNSPECIFIED
Depositing User:	Tn Yusuf Jailani
Date Deposited:	04 Oct 2016 01:55
Last Modified:	04 Oct 2016 01:55
URI:	http://repository.unair.ac.id/id/eprint/32182
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