RAHAYU SETIYANINGSIH, 091170101 (2016) Mekanisme Repair Endotel Pembuluh Darah Pada Tikus Wistar (Rattus norvegicus) Model Aterosklerosis Yang Diberi Latihan Fisik Dan Stem Cell Exogenous. Disertasi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Objectives: This research is aimed to well recognize the effect mechanisms of measured and regular physical exercise administration while given the mesencymal stem cell by intravene to the progress of heart blood vessel endothelium to atherosclerosis. Material and Methods: This research is a true experiment research using post test only control group design. Sample of this research is male white murine (Rattus norwegicus) of Wistar strain in the number of 24 murine controlled homogenously under the inclusion criteria, which is atherosclerosis, aged 20 weeks, weighed 180-200 grams, inhybrid, and healthy condition characterized by good appetite and normal behavior. Rattus Norwegicus conforming inclusion criteria was divided into four groups, those were a group of control, a group of measured and regular physical exercise of moderate intensity treatment, a group of measured and regular physical exercise of moderate intensity treatment with the administration of mesenchymal stem cell, and a group of mesenchymal stem cell administration without moderate intensity physical exercise. Results: Result of manova test was obtained and demonstrated that significant result was on IL-6 (p<0,001), VEGF (p<0,001), CXCR 4 (p<,001), SDF-1 (p<0,001). This defined an expression difference of IL-6, VEGF, CXCR 4, and SDF-1 amongst the treatment groups. Insignificant result was on SOD (p=0,058) which elucidated that SOD expression difference was not found on the treatment groups. In a pathway analysis, repairing mechanism by two pathways, there are administrations of moderate intensity physical exercise and exogenous mesenchymal stem cell. Conclusion: The attempts of lowering atherosclerosis risk factor is one of protecting blood vessel endothelium ways. Interpretation of this mechanism is expected to open new perspectives of atherosclerosis prevention and medication.

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