Siti Sukarnah, 090610036/M (2008) POTENSI KHITOSAN DALAM MENGHAMBAT KELAINAN KONGENITAL EKSTERNAL FETUS DAN PENURUNAN KEMAMPUAN REPRODUKSI INDUK MENCIT (Mus musculus) AKIBAT PEMBERIAN ASAM RETINOAT. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The aim of the administrasion of retinoid acid at dose of 60mg/kg into female mus musculus is to know the teratogenic effect of vitamin A in the growth of fetus ( number of fetus, number of fetus resorption ,weigth of fetus ,and presentage of external malformation) .The teratogenic and toxic effect are results of administrasion of one dose oral retinoid acid. The number of fetus ,the number of fetus resorbtion ,the weigth of fetus ,and the percentage of of normality external are calculated to know the teratogenic effect. The teratogenic and toxic effect which is resulted by the administrasion of retinoid acid are blocked by chitosan that is administered one hour after induction of retinoid acid. The result of macroscopic study shows that the administration of chitosan after induction of retinoid acid in the 10th days of pregnancy resulted in increasing the fetus weight, fetus, implantation of fetus and decresing the number of fetus resorbtion (< 0.05). Chitosan that is administered on the highest dose in the research (third group) increases number of weight fetus, fetus, implantation fetus and decreses the number of fetus resorbtion (< 0.05). When chitosan was administrated on the highest dose in the resech (third group), it reduces external malformation, except on the extromelia and micromelia. They remain in the previous number.

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