MOHAMMAD ZEN RAHFILUDIN (2011) ANALISIS SUPLEMENTASI SENG TERHADAP RESPONS IMUN NARAKONTAK KUSTA YANG SEROPOSITIF. Disertasi thesis, UNIVERSITAS AIRLANGGA.
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Abstract
Incidence of leprosy showed no decline; it happened since there was no prevention or preventive medicine for seropositive contact of leprosy patients. Zinc supplementation was expected to improve their cell mediated immunity response The aim of this research was to analyze the influence of zinc supplementation toward immunity response of seropositive contact of leprosy patients.This research was experiment with pre post control group design. Research sample was seropositive contact of leprosy patients with marginal zinc deficiency. The amount was 22 people, 11 people for each group treatment and control. Seropositive leprosy was determined by examining IgM anti PGL - 1 level using Elisa method. Zinc plasma level was measured with atomic absorption spectrophotometer. Zinc supplementation dosage was 40 mg/per day as zinc sulphate given for 90 days. IFN gamma and IL - 2 level were measured with Elisa method.The result showed no significant increase of IFN gamma and IL - 2. However, a major decline of IFN gamma and IL - 2 happened on control group. There was significant change of IL-2 level between both groups.Zinc supplementation could modulate T - Cell to maintain IFN gamma and IL - 2 level productions since zinc took part in intracellular signal to produce cytokine. Zinc supplementation ineffectiveness happened since Mycobacterium leprae could impair host immune response, high ratio of phytate:zinc, Mycobacterium leprae capability to compete the host by zinc acquisition, supplementation length, and zinc interaction with other nutrients. Further research needs to be done by increasing the length of supplementation and giving others micronutrient.
| Item Type: | Thesis (Disertasi) | ||||||
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| Additional Information: | KKA KK Dis K 13/12 Rah a | ||||||
| Uncontrolled Keywords: | seropositive leprosy, zinc supplementation, IFN gamma, IL - 2 | ||||||
| Subjects: | R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine > RA421-790.95 Public health. Hygiene. Preventive medicine > RA638 Immunity and immunization in relation to public health | ||||||
| Divisions: | 09. Sekolah Pasca Sarjana > Ilmu Kedokteran | ||||||
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| Depositing User: | Nn Husnul Khotimah | ||||||
| Date Deposited: | 2016 | ||||||
| Last Modified: | 09 Jun 2017 17:55 | ||||||
| URI: | http://repository.unair.ac.id/id/eprint/36515 | ||||||
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