FAHRUN NUR ROSYID (2009) EFEK PEMBERIAN REBUSANN DAUN TEMBAKAU KERING TERHADAP KADAR PLATELET DARAH DAN WAKTU PROTROMBIN PADA TIKUS PUTIH (RA TTUS NOR VEGICUS) GALUR WISTAR. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Nicotine that presents in dry tobacco leaf is also able to mobilize compartment platelet through symphatetic activity that results in the increase of blood platelet count (thrombocytosis). The objective of this study was to prove the effect of nicotine in dry tobacco leaf on blood platelet count and prothrombin time. This study used separate sample pretest-posttest control group design, involving male Wistar strain Rattus norvegicus aged of 3 - 3.5 months. The independent variable was dry tobacco leaf boiled (0.6 ml/200 mg rats BW) and the dependent variables were blood platelet count (/µl) and prothrombin time (second). Pretest data were taken from control group and posttest data were dry tobacco leaf boiled for 5 days. The results showed that in dependent variable of blood platelet count, there was significant difference between control group and group receiving dry tobacco boiled (p : 0.000). In the variable of prothrombin time, there was no difference between control group and group receiving dry tobacco leaf boiled (p : 0.200). The result indicated that the provision of dry tobacco leaf boiled was able to increase blood platelet count and did not increase prothrombin time. (File Fultext Tidak ada, Mohon Lihat Langsung Koleksi Tesis)

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