FADILATUS SUKMA IKA N, 101143011 (2013) PENINGKATAN TNFα SERUM DARAH DAN PENURUNAN FAAL PARU PADA PEKERJA TERPAPAR ENDOTOKSIN LPS DALAM DEBU KAPAS. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

LPS Endotoxin containing cotton-dust leads to airway inflammation, lung function decline, and pneumonitis. The objective of this research was to analyze the correlation between decline of lung function, increase of serum TNF level and exposure of LPS endotoxin containing cutton-dust. This study was analytic observational design using by cohort prospectional approach. It was conducted on Tulangan Subdistrict, Sidoarjo.The population was all the cotton workers in cutton factory as a study group and village administrator as control group. Sixteen samples were taken as sample of control group, while twenty three samples were taken from control group. Techniques for collecting data were i nterview, dust exposure measurement, endotoxin LPS level, blood serum TNF assay and spirometry. Serum TNF and lung function were measured before and after work. The result showed that LPS endotoxin in personal dust samples was significantly related to increased level of serum TNF (p=0,027), Δ%FEV1 (p=0,002) and ΔFEV1 (p=0,001) among cotton worker and respiratory complaints (p=0,026), and ΔFVC (p=0,001) on village administrator. LPS endotoxin in ambient dust samples was significantly related to Δ%FEV1(p=0,020) and ΔFEV1(p=0,022) among cotton worker. There was no LPS endotoxin in ambient dust samples on village office. There was significant correlation between personal dust with Δ%FEV1(p=0,006) and fEV1(p=0,006)Δ%FVC(p=0,005) and ΔFVC(p=0,002). There was no correlation between ambient dust with increased level of serum TNF, lung function decline and respiratory complaints, and there was no correlation between characteristic of workers with increased level of serum TNF, lung function decline and respiratory complaints, except respiratory complains with packyears (p=0,039). Conclusion:There is correlation between increase of serum TNF, decline of lung function and exposure of LPS endotoxin containing cutton-dust. It�s sugeested that safety individual protection is needed

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