Septi Handayani, NIM011041011 (2013) PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN KECOMBRANG (Etlingera elatior) TERHADAP AKTIVITAS ALDOSA REDUKTASE LENSA DAN ERITROSIT TIKUS PUTIH (Rattus norvegicus) GALUR WISTAR DENGAN DIABETES MELITUS (PENELITIAN EKSPERIMENTAL LABORATORIS). Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This research was to prove the ethanol extract of kecombrang (Etlingera elatior) leaves could decrease lens and erythrocyte aldose reductase activity. True experimental research with randomized posttest only controls group design was ferformed. Thirty-five male white rats (Rattus norvegicus) Wistar strain were divided into five groups (each comprised seven rats). Four groups which injected by Streptozotocin (STZ) 60 mg/kgBW were K(+) (fed by Na-CMC 1% solution only), P1 (fed by 100 mg/kgBW kecombrang leaves extract in Na-CMC 1% solution), P2 (fed by 150 mg/kgBW kecombrang leaves extract in Na-CMC 1% solution), and P3 (fed by 200 mg/kgBW kecombrang leaves extract in Na-CMC 1% solution). One group (K(-)) which not injected by Streptozotocin (STZ) was fed by Na-CMC 1% solution only. The mean activity of aldose reductase lens between groups (K(+), K(-), P1, P2, and P3) was found that there was no significant mean difference (p> 0.05). Group which fed by 100 mg/kgBW, 150 mg/kgBW and 200 mg/kgBW kecombrang leaves extract had lower erythrocyte aldose reductase activity than group which was not fed by kecombrang leaves extract significantly (p<0,05). This research suggest that ethanol extract of kecombrang (Etlingera elatior) leaves decrease erythrocyte aldose reductase activity in white rats (Rattus norvegicus) Wistar strain with diabetes mellitus but ethanol extract of kecombrang (Etlingera elatior) leaves was not proven to affect lens aldose reductase activity in white rats (Rattus norvegicus) Wistar strain with diabetes mellitus.

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