Renata Prameswari (2016) PROFIL KADAR IMUNOGLOBULIN E SERUM, INTERLEUKIN-4, INTERFERONGAMMA LIMFOSIT T CD4+ DAN INDEKS SCORING ATOPIC DERMATITIS (SCORAD) PASIEN DERMATITIS ATOPIK ANAK YANG DITERAPI Lactobacillus plantarum DAN PLASEBO. Thesis thesis, Universitas Airlangga.

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Abstract

Background: Atopic dermatitis (AD) is a chronically relapsing skin disease that occurs most commonly during early infancy and childhood. Probiotics in AD could be considered for a treatment option. This study conducted to examine whether of Lactobacillus plantarum (LP) improves AD in children. Purpose: To evaluate total immunoglobulin (IgE) serum level, interleukin (IL) -4 and interferon-gamma (IFN-γ) T lymphocyte CD4+ and Scoring Atopic Dermatitis (SCORAD) index in children with AD treated with LP and placebo. Method: In this experimental study, 22 children aged 0-14 years was randomized to given LP 1010 Colony Factor Unit (CFU) and placebo once daily for 12 weeks. Total IgE serum, IL-4, IFN-γ level and SCORAD index were evaluated in week 14. Result: 12 patient in probiotic group and 10 patient in placebo group completed the study. Total IgE serum level in probiotic group at week 14 is 504,533 ± 415,686 while in placebo group is 909,580 ± 885,051. IL-4 in probiotic group at week 14 is 4,277 ± 4,892, while in plasebo group is 5,815 ± 6,633. IFN-γ in probiotic group at week 14 is 0,528 ± 0,63, while in placebo group is 0,684 ± 1,006. The SCORAD score at week 14 was lower in the probiotic group than in the placebo group (18,533 + 14,200 vs 22,040 + 8,817). Conclusions: Our results suggest that supplementation with probiotic LP is beneficial in the treatment of children with AD

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