Aniek Setiya Budiatin, M.Si.,Apt and Ferdiansyah, Dr.,dr.,Sp.OT. and ToetikAryani, Dra., M.Si., Apt and Fathia Ramadiani, S.Farm.,M.Farm Apt (2013) MATRIKS DAN SCAFFOLD KOMPOSIT BOVINE HYDROXYAPATITE-GELATIN SEBAGAI SISTEM PENGHANTARAN ALENDRONAT PADA CELAH (DEFECT) TULANG AKIBAT KANKER TULANG ATAU OSTEOPOROSIS. UNIVERSITAS AIRLANGGA, Surabaya. (Unpublished)

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Abstract

Bovine hydroxyapatite and gelatin (BHA-riEL) composite were used as hone Ii a biodegradable drug delivery system (DDS) filr the administration of alendronat I treatment of bone defect was caused by osteoporosis and bone cancer. were ynthesi/ materials, which ovoid activaties of osteocia . are exclusively composed of alcfll; bioactive bovine hydroxyapatite and gelatin were manufacture as pellet 01 thl components and characterized in vitro and in vivo. (ross-linking reaction was rClI control the water penetration, swelling and release of alendronate from the rellet characterization with FTIR ; SEM and alendronate release from the pellet at conditiup· and temperature body were studied tor 4 weeks. The Result that the BHA-GEL-ALE cross-linking with glutaraldehyde (t,, biodegradable,nontoxic to human osteoblasts and promote their proliferation. as hon and it was able to control release ALE which inhibit osteoclas activaties as drug ·it system (nOS) ofalendronate.

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