Saputro Doso, Iswinarno and Zarasade, Lobredia and Putra Swadharma, Bobby (2014) INTRA VENOUS VITAMIN C ADMINISTRATION DECREASES NITRIC OXIDE SERUM LEVEL IN SEVERE BURN INJURY. Folia Medica Indonesiana, 50 (3). pp. 143-147. ISSN 2355-8393

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Abstract

Nitric oxide (NO) may cause systemic hypotension and apoptosis, contributing to tissue damage and multiple organ failure in severe burn, which increases Nitric Oxide Syntase (NOS) enzyme activity and NO release. Proinjlammatory cytokines involves in NOS induction and activation and NO release. Vitamin C suppresses proinflamatory cytokines production, so NO production is inhibited. This study aimed to review intravenous vitamin C 3000 mg effect on NO serum level in severe burn Injury. This study used randomized pre-test and post-lest controlled group design in I 2 severe burns patient at Burn Unit. Dr. Soetomo Hospital, Surabaya.NO was examined in 12 patients who were divided into 2 groups. Control group (Kl) received vitamin C 2 x 400 mg/24 hour for 72 hours and treatment group (K2) received intravenous vitamin C 3000 mg for 72 hours. NO was taken from blood serum and observed by Grease method. Results were analyzed by Paired T-Test and statistical assays with p < 0.05. NO serum level in Kl showed no significant increase compared to day I of the day 4 (p = 0.21) and NO serum level had 110 significant decrease on day I than that on day 4 (Kl) (p = 0.06). NO level decreased significantly in K2 compared to that in Kl (p = 0.02). Kl showed no significant result in Blood Gas Analisis, Blood Urea Nitrogen, and Serum Creatinine, while Kl showed significant result in White Blood Cell (p = 0.01). In conclusion, intravenous vitamin C administration decreases nitric oxide serom level in severe burn injury.

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