SUPRIATIN, 059912176 (2003) UJI TOKSISITAS AKUT DAN TERATOGENIK FRAKSI ETANOL 60% DAN FASA AIR DAUN GENDARUSSA VULGARIS NEES PADA MENCIT. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

According to research on antifertility activity of Gendarussa vulgaris Nees, it's found to be developed as herbal medicine. Hence, it's must be followed by premedical research on animal then continued to clinical trials. One of the premedical research is toxicity test. It's needs to be done to know of the safety level usage. Acute toxicity and terratogenic test ofethanol 60% fraction and water phase ofGendarussa vulgaris Nees leaf had been done. The acute toxicity test found that LD5i.I value of the ethanol 60% fraction and water phase on mice were 17,82630 glkg body weight and 15,63389 glkg body weight respectively. Hence could be concluded that ethanol 60% fraction and water phase of Gendarussa vulgaris Nees leaf was classified at practically non-toxic substance. The termtogenic test showed no bones malformation on offspring. The data analyzed with ANOV A «(l = 0,05) showed that there is no significant difference on total amount, average weight, average length offspring of all groups. Hence could be concluded that ethanol 60% fraction and water phase of Gendarussa vulgaris Nees leaf did not show terratogenic effect

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