Sosiawan, Agung and Dea Kartika, Antonia and Listiana K, Indah (2012) Perbedaan Pemberian Kombinasi Bisfosfonat dan Kalsium Laktat terhadap Jumlah Osteoklas Aktif pada Luka Pencabutan Gigi Tikus (Strain Wistar). Oral Biology Dental Journal, 4 (1). pp. 40-45. ISSN 1979-8814

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Abstract

Background. Bone is living tissue whose cell always suffered degeneration and regeneration. many factors that can cause destruction of bone cells, one of which is age and lifestyle. Mechanism of bone destruction due to osteoclasts destroying bone and also the production of collagenase acid and proteolik enzyme that causes increased bone resorption. This mechanism is also called Osteoporosist. Bisphosphonates are used as an osteoporosis therapy, Bisphosphonate can reduce bone resorption by osteoclasts by binding to bone surface and inhibit osteoclast work by reducing the production of protons and lysosomal enzymes. Bisphosphonate causes a decrease in the production of osteoclasts so that bone can not afford to destroyed the bones, so the process can reduced bone resorbtion. Purpose. This study aims to compare the number of osteoclasts between bisphosphonate and bisphosphonates with calcium added in rats. Method. Comparing the number of osteoclast in rat tooth sockets, divided into three groups. The control group without treatment, an additional group with oral bisphosphonates, and group with an oral bisphosphonate that calcium lactate was given orally. Result. This research founds that the use of bisphosphonates have a lower number of osteoclasts compared by bisphosphonates with calcium added. Excessive consumption of calcium will cause hypercalcemia that would regulate the body by removing calcium from the body, including calcium from the bone. Conclusion. There are differences between the groups without treatment by treatment group, but group with bisphosphonate gives better results than the group with bisphosphonate plus calcium lactate.

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