DWI FATMAWATI, 051211131174 (2016) UJI IN VITRO AKTIVITAS ANTIMALARIA EKSTRAK DAUN Sauropus androgynus (L.)Merr DENGAN EKSTRAKSI BERTINGKAT TERHADAP Plasmodium falciparum. Skripsi thesis, Universitas Airlangga.

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Abstract

The aimed of this study was to determinate antimalarial activity of nhexane extract, chloroform extract, and 96% ethanolic extract of Katuk (Sauropus androgynus (L.) Merr) leaves. In vitro test of the n-hexane, chloroform, and 96% ethanolic extract performed using 3D7 strain of Plasmodium falciparum which has been synchronized and incubated for 48 hours.The concentration of the test solution of n-hexane, chloroform, and 96% ethanolic extract were used at 100 ug/ml, 10 ug/ml, 1 ug/ml, 0.1 ug/ml, 0.01 ug/ml. The results showed that the 96% ethanolic extract of Sauropus androgynus (L.) Merr leaves have most active antimalarial activity with IC50 value of 1,917 ug/ml, and chloroform extract showed active antimalarial activity with IC50 value of 6,497 ug/ml, while n-hexane extract showed inactive antimalarial activity with IC50>100 ug / ml. Key words: Sauropus androgynus (L.) Merr, Plasmodium falciparum 3D7, antimalarial activity, in vitro

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