Meyta Riniastuti, NIM011181409
(2016)
ANALISIS EKSPRESI Cdk6 DAN Ki-67 PADA NEOPLASMA KELENJAR LIUR.
Thesis thesis, Universitas Airlangga.
Abstract
Background: Tumors with broad spectrum can arise in salivary glands and giving diagnostic difficulties in some subtypes due to morphologic similarities. Immunohistocemistry studies done to differentiate between benign and malignant neoplasms of salivary glands are very few, including Cdk6 and Ki-67. Cdk6 role in tumorigenesis, halting cellular proliferation and differentiation. Ki-67 is actively expressed in cells that are proliferating, particularly neoplasms.
Objective: To analyze differences of Cdk6 and Ki-67 expression in benign and malignant salivary gland neoplasms, as well as analyzing the correlation between the Cdk6 and Ki-67expression in the salivary gland neoplasms.
Methods: This is an analytic observational study with cross sectional design. Samples were taken in proportion, each 15 samples of benign and malignant salivary gland neoplasms, derived from pathological archives during period of 1 January 2011-30 June 2013. Immunohistochemical staining with Cdk6 and ki-67 monoclonal antibody were performed. Differences in Cdk6 and Ki-67 expression of both group were analyzed using Mann Whitney. The correlation between the Ki-67 and Cdk6 expression were analyzed using Spearman.
Results: There were significant differences in the Cdk6 and Ki-67 expression between benign and malignant salivary gland neoplasms.The expressions of Ki-67 have a cut-off point of 6.50%. There was a significant correlation between Cdk6 and Ki-67 expression in the salivary gland neoplasms.
Conclusion: Cdk6 and Ki-67 can be used to distinguish between benign and malignant neoplasms of the salivary glands. There were correlation between Cdk6 and Ki-67 expression in the salivary gland neoplasms.
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