PENGARUH ASAM 4-HIDROKSISINAMAT DAN ASAM 4-METOKSISINAMAT TERHADAP AKTIVITAS TIROSINASE

SEPTIANA, 059912172 (2004) PENGARUH ASAM 4-HIDROKSISINAMAT DAN ASAM 4-METOKSISINAMAT TERHADAP AKTIVITAS TIROSINASE. Skripsi thesis, Universitas Airlangga.

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Abstract

Tyrosinase is known to be a key enzyme for melanin biosynthesis. Therefore, inhibition in tyrosinase activity will cause a decreasing in melanin production. The inhibition of cinnamic acid and its derivatives against tyrosinase has been studied as the effort to find a new effective skin-lightening agent. 4hidroxycinnamic acid and 4-metoxicinamic acid as two of cinnamic acid derivatives was tested to know its effect on inhibiting tyrosinase. To Asses the efficacy of tyrosinase inhibition, tyrosinase activity using LTyrosine as a substrate was assayed spectrofotometrically with the dopachrome method. Michaelis-Menten constant (Km) and maximum velocity (Vmax) of the enzyme activity were showed by Lineweavar-Burk's plots.

Item Type: Thesis (Skripsi)
Additional Information: FF 102-04 Sep p.
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM
SEPTIANA, 059912172UNSPECIFIED
Contributors:
ContributionNameNIDN / NIDK
Thesis advisorH. PURWANTO, DR.UNSPECIFIED
Depositing User: Mr Bambang Husodo
Date Deposited: 03 Apr 2017 19:35
Last Modified: 03 Apr 2017 19:35
URI: http://repository.unair.ac.id/id/eprint/55732
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