YUNITA RHOHMAWATI, 051211131176 (2016) PENGARUH KONSENTRASI POLOKSAMER 407 DAN WAKTU PENGGILINGAN TERHADAP KARAKTERISTIK FISIK NANOKRISTAL HESPERETIN (Dibuat dengan Metode Penggilingan Basah). Skripsi thesis, Universitas Airlangga.

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Abstract

Hesperetin is a flavanone compound with many pharmacological effects. However, its poor solubility in water and fast elimination from the body causes low bioavailability of this compound when given orally. Formulating hesperetin as nanocrystals could overcome these problems. Additionally, the use of stabilizer with sustained release properties,such as poloxamer 407, might prolong its elimination. The aim of this study is to optimize the effective concentration of poloxamer 407 in producing physically stable hesperetin nanosuspension with particle size smaller than 200 nm.0.5 g of Hesperetin powder was dispersed into aqueous poloxamer 407 (15%, 25% and 50% w/w) then milled for up to 48 h. Samples were taken every 5, 24 and 48 h and analyzed for their particle sizes. Final nanosuspensions were stored for 2 weeks at 8oC. Nanosuspensions were then dried to produce nanocrystals and analyzed for its crystallinity using XRD. Particle size of all nanosuspensions obtained were <200 nm with particle size increasing <50 nm. The smallest size obtained was 141±7 nm for nanosuspension stabilized 50% w/w of poloxamer 407. Based on the XRD evaluation, the nanocrystals obtained were remained crystalline. Poloxamer 407 at concentration 50% w/w was able to form smallest and stable hesperetin nanocrystals. Keywords: hesperetin, poloxamer 407, milling, nanosuspension, nanocrystals

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