Mustika, Arifa (2014) Keamanan Penggunaan Ekstrak Etanol Singawalang (Petiveria alliacea) Pada Fungsi Ginjal Mencit. In: Prosiding Annual Scientific Meeting Pokja Nutrigenomik. Bagian Biokimia Fakultas Kedokteran Universitas Gajah Mada, pp. 46-49. ISBN 978-602-70556-0-5

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Abstract

Diabetes mellitus is a disease caused by multiple genetic faclors. Extract ethanol of singawalang leaves (Petiveia alliacea) have been used empirically for treatment of diabetes. Until now, there is a little evidence base about a safety of the extract ethanol of singawalang leaves. The aim of this study was to determine the sub-acute toxicity of the Extract ethanol of singawalang leaves on renal function of mice . This research is an experimental study with a completely randomized design. Thirty- two male mice (Mus musculus) were divided into four groups . The first group was the group that given the ethanol extract singawalang leaves at a dose of 90 mg/kgbw, the semnd group was the group that given the ethanol extract singawalang leaves at a dose of 180 mg/kgbw, the third group was the group that given the ethanol extract singawalang leaves at a dose 360 mg/kgbw and the fourth group was a control group that were given distilled water. The ethanol extract singawalang leaves were administered orally, once daily for 21 days. On the day 22th , mice were euthanized and blood have been taken. Blood levels of urea nitrogen and serum creatinine were evaluated. Data were analyzed by Kruskal Wallis . The results have been showed that the mean levels of urea nitrogen in the first group was 19.25 mg/dL , second group was 18.83 mg/dl , third group was 18.37 mg/dl and in the control group was 16.50 mg/dl . The mean levels of serum creatinine in the first group was 0.31 mg/dl, semnd group was 0.32 mg/dl, third group was 0.29 mg/dl and in the control group was 0.29 mg/ dL. The statistical tests have been found that there was no significant difference between control and treatment groups both at the levels of urea nitrogen and serum creatinine levels. The ethanol extract of Petiveria alliacea al a dose of 90 mg/kg , 180 mg/kg , 360 mg/kg did not affect renal function of mice.

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