AISYAH SHAUMANUR ARTHA HIDAYAH, 061211133053 (2016) EFEK HEPATOPROTEKTOR EKSTRAK BIT MERAH (Beta vulgaris L.) TERHADAP GAMBARAN HISTOPATOLOGI HEPAR MENCIT (Mus musculus) YANG DIPAPAR Pb. Skripsi thesis, Universitas Airlangga.

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Abstract

The purpose of this study was to know hepatoprotector potential of red beet (Beta vulgaris L) extract in lead induced mice. The research has been done on July, 2th 2015-August, 19th 2015 at Department of Veterinary Pathology, Faculty of Veterinary Medicine, Airlangga University. Twenty five male mice (Mus muculus) aged 60-90 days with BW 27-32 g were used. These animals were divided into five groups (K-, K+, P1, P2, and P3). K- were treated with CMC Na 0,5% 0,1 ml/bw/days, K+ were treated with lead 20 mg/bw/day, P1 were treated with extract of red beet 200 mg/bw/day and lead 20 mg/bw/day, P2 were treated with extract of red beet 400 mg/bw/day and lead 20 mg/bw/day, and P3 were treated with extract of red beet 800 mg/bw/day and lead 20 mg/bw/day. This research has been conducted for 27 days to determine the toxic effects of lead on the liver. The data were analyzed using Kruskal-Wallis test and Post Hoc test. Which performed with SPSS v20.0 for windows. The result showed there were significant (p<0,05) different between treatment groups, which is all dosage treatment had been proved have potential to protect on hepatosit. In conclusion, the research demonstrated that histopathological changes due to lead-induced (20 mg/kgBW) could be treated effectively of red beet extract on the target organ.

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