FAIZATUL KHUSNIA, 061311133122 (2017) PENGARUH PEMBERIAN VAKSIN SUBUNIT LIPOPOLISAKARIDA Brucella abortus DALAM ADJUVANT MONTANIDE ISA 70 PADA DOMBA TERHADAP TITER ANTIBODI dan KADAR IFN-γ. Skripsi thesis, Universitas Airlangga.

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Abstract

The aims of this study is to determine the effect of vaccine sub unit lipopolysaccharide Brucella aborus in adjuvant Montanid ISA 70 in sheep antibody titer and levels of IFN-γ with different doses. This study used 18 sheep as experimental animals, whit 3 different treatments groups for each treantments group consist of 6 sheep. Group P0 : control, treatment group P1 : 50 μg / ml of LPS Brucella abortus in adjuvant Montanide ISA 70, treatment group P2 : 100 μg / ml LPS Brucella abortus in adjuvant montanide ISA 70. Observation were done at 2nd and 4th week post vaccination. In this study, data of antibody titer and data of IFN-γ level were analyzed by ANOVA Univariated test followed by Tukey test. The results showed that the sub-unit of Brucella abortus lipopolysaccharide vaccine in adjuvant Montanide ISA 70 had an effect on antibody titer and IFN-γ level. Different doses have an effect on the value of antibody titers and levels of IFN-γ. At a dose of 100 μg / ml showed an antibody titer higher than the 50 μg / ml dose. At a dose of 50 μg / ml showed higher IFN-γ values than did doses of 100 μg / ml. Post vaccination in the 2nd and 4th weeks did not have a significant effect on the antibody titer and the level of gamma interferon.

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