Aty Widyawaruyanti, - and Deri Astrianto, - and Hilkatul Ilmi, - and Lidya Tumewu, - and Dwi Setyawan, - and Endang Widiastuti, - and Lilis Dachliyati, - and Indah Tantular, - and Achmad Fuad Hafid, - (2017) Antimalarial Activity and Survival Time of Andrographis paniculata Fraction (AS202-01) on Plasmodium berghei Infected Mice. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 8 (1S). pp. 49-53. ISSN 0975 - 8585

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Abstract

The rapid spread of resistance encourages the search for new actlrle compounds. Andrographis poniculota commonly known as sambiloto was empirically used as traditbnal medicine in lndonesia to cure malaria. This study aims to determine antimalarial activity and survival time of A. poniculoto fraction from 70% ethanolic extract (namely AS202-01) on Plasmodium berghei infected mice. Antimalarial in vivo study was conducted based on Peter's 4-days suppressive test. Thirty healthy Balb/c male mice, divided into 6 groups (n = 5), were infected intravenously with 1x106 pardsitized erythrocytes of P. bergfiei. lnfected mice were treated at a dose of 5.25, 12.5, 25 and 50 mg^g BW, br/ke a day lor four days, the untreated group of mice received CMC-Na 0.5% and the control group treated with chloroquine (10 mg/kg BW). Thin blood smears giemsa staining were made every day for seven days and observed under microscope to count parasitemia and calculate inhibition of parasite's Browth. Probit analysis was conducted to determine effective dose (ED5o) value. Observation of antimalarial effect of As2o2-01 was continued until 14 days to evaluate survival time of infected mice. The results showed that AS202{1 was inhibited P- berghei growth with EDso value of 6,75 me/kg 8W. lt was classified as a highly active antimalarial substance. The AS202{1 was also ignificantly able to increase survival time of infected mice compared to untreated group

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