Johanes Nugroho and Soemantri, Djoko (2005) Whats New in Diabetes & CAD Management. In: The 14th annual Acientific Meeting of the Indonesian Heart Association "Expanding the Horizon of Cardiometabolics". The Indonesian Heart Association, Fakultas Kedokteran Unair, pp. 67-72.
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Abstract
Most patients with tlpe 2 diabetes have insulin resistance. Indeed, insulin resistance seems to predispose to both CVD and diabetes. Research suggests that insulin resistance is a multisystem disorder that induces multiple metabolic alterations. Factors that conribute to insulin resistance are genetics, obesity, physical inactivity, and advancing age. Patients with insulin resistance often have abdominal obesity. Metabolic risk factors that occur commonly in patients with insulin resistance are atherogenic dyslipidemi4 hypertension, glucose intolerance, and a prothrombotic state. Although monotherapies can, at least in theory, improve both metabolic defects underlying most cases of type 2 diabetes, monotherapies of all types gradually fail to correct hlperglycaernia as diabetes progresses. Such progressive treatment failures might be minimised by combining two separate agents, each highly effective in correcting one of two defects. There are a wide range possible combinations of sulphonylureas and metforrnin. Nevertheles , only glibenclamide and metformin are evidence-based, with several published clinical studies. These have shown that this combination provides enhanced glycaemic control in type 2 diabetes and cardiovascular protection, compared with ttnt offered by either monotherapy.
| Item Type: | Book Section | ||||||
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| Subjects: | R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research | ||||||
| Divisions: | 01. Fakultas Kedokteran > Ilmu Penyakit Jantung | ||||||
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| Depositing User: | Bayu Yulianti | ||||||
| Date Deposited: | 19 Sep 2017 21:46 | ||||||
| Last Modified: | 19 Sep 2017 21:46 | ||||||
| URI: | http://repository.unair.ac.id/id/eprint/61616 | ||||||
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