DIAN AFIKASARI, 061211132052 (2016) PENGARUH PEMBERIAN INDOMETASIN DAN EKSTRAK BATANG PISANG AMBON (Musa paradisiaca var. sapientum ) TERHADAP GAMBARAN HISTOPATOLOGI ILEUM TIKUS (Rattus norvegicus). Skripsi thesis, Universitas Airlangga.

Preview	Text (ABSTRAK) KH.315.17 . Afi.p - ABSTRAK.pdf Download (23kB) | Preview
	Text (FULLTEXT) KH.315.17 . Afi.p - SEC.pdf Restricted to Registered users only until 2 October 2020. Download (1MB) | Request a copy

Abstract

Indomethacin is Non-Steroidal Anti Inflammatory Drug (NSAID) such as fever, rheumathoid arthritis treatment and post surgery treatment. In this research, 3,15 mg/kg BB indomethacin was given orally. Indomethacin has side effect on ileum which is caused Inflammatory. The flavonoid in ethanol extract of ambon banana stem (Musa paradisiaca var.sapientum) had possibility to be used as a therapy. This research was aimed to determine the histopatology of ileum rats. This experiment used male rats (Rattus norvegicus) aged 8-12 weeks and weigh 150 grams, were divided into five experimental groups, those were control-rats, Indomethacin induced rats, and group of ambon banana stem extract with dose of P1 = 100 mg/kgBW, P2 = 300 mg/kgBW, P3 = 400 mg/kgBW. Each ileum specimen was processed and histopathological changes were observed. Score of submucosal edema, PMN infiltration, the number of goblet cell, epithelial integrity as qualitative data were analyzed with Kruskall Wallis test continued by mann whitney test.The result of the study showed that ethanol extract of ambon banana stem could repaired damage of ileum histopathology (p<0,05). Ileum histopathology repaired was marked by improvements epithelial cells of ileum.

Actions (login required)

View Item