GILANG NUGRAHA, NIM011414153023 (2017) PENGARUH KADAR TRIGLISERIDA TERHADAP AKURASI PENENTUAN ESTIMASI SMALL DENSE LOW DENSITY LIPOPROTEIN-CHOLESTEROL DENGAN FORMULA SRISAWASDI. Thesis thesis, Universitas Airlangga.

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Abstract

Small dense low density lipoprotein (sdLDL) is the smallest fraction of LDL particle with diameter ≤25,5 nm. sdLDL particle is a highly atherogenic lipoprotein. It was even reported to increase CHD risks up to three times higher. sdLDL measurement is usually perfomed by complex instrumentation and complicated technique, thus it is hard to be perfomed in daily clinical practices. In 2011, Srisawardi et al developed a technique for sdLDL-C estimation using an equation by counting routine lipid profile tests. It was reported that an increase of TG concentrations could decrease sdLDL-C correlation estimation. 88 serum samples were collected from Dr. Soetomo Hospital. TC, TG, HDL-C and dLDL-C from those samples were also measured. sdLDL-C was measured in Parahita Laboratory, Dharmawangsa with homogeneous enzymatic assay method. Statistical analysis showed there was no difference on Srisawardi sdLDL-C formula result by homogeneous enzymatic assay method (P=0,000). The decrease of correlation value was found in TG concentration group was <100 mg/dL to group with TG concentration was 200-299 mg/d. The difference correlation value in each TG group, do not affect the accuracy examination sdLDL-C in the formula Srisawasdi (P=0.720) to the concentration of TG <400 mg/dL, with a bias in the whole sample is 34.15 %. Limitations sdLDL-C on Srisawasdi formula can only be used at concentrations of triglycerides less than 200 mg/dL, with intra-laboratory quality assurance of well-controlled. Suggestions study, further research is needed to determine the normal value sdLDL-C in the formula Srisawasdi et al.

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