TRISNA SARI DEWI, 061311133200 (2017) PENGARUH PEMBERIAN SALEP EKSTRAK BUAH OKRA (Abelmoschus esculentus) SECARA TOPIKAL TERHADAP KECEPATAN KESEMBUHAN LUKA BAKAR TIKUS (Rattus Norvegicus) SEBAGAI HEWAN MODEL. Skripsi thesis, Universitas Airlangga.

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Abstract

This research aimed to prove the effect of Okra (Abelmoschus esculentus) extract ointment to inflammation, angiogenesis, collagen, and granulation on the rate wound healing of skin burn of rat (Rattus norvegicus). This research used 30 white rats as experimental. The rats were randomly divided into 10 groups based on time and treatment. The treatment consist of untreated burns for 3nd and 10th days (K1 and K2), burnazin treatment for 3nd and 10th days (K3 and K4), treatment using 3% concentration of okra for 3nd and 10th days (P1 and P2) , 6% concentration of okra for 3nd and 10th days (P3 and P4), and 12% concentration of okra extract for 3nd and 10th days (P5 and P6). Observation were scheduled on the 3rd and 10th days. White rats were injured with 2nd degree of deep partial thickness burn in dorsal region of the rat body, and then treated until day 3nd and day 10th. The skin samples were examined the presence of inflammation, angiogenesis, collagen and granulation. Then, Kruskall-Wallis test followed with Mann-Whitney test of statistical analysis. The result showed changed in wound healing of skin burn. The best result was K3, burnazin treatment for 3nd days, followed by P1 it was treatment using 3% concentration of okra for 3nd days. The most severe damage was occured on K1 caused untreated burns.

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