MALIKA SAMLAN, 021218076307 (2017) EFEKTIFITAS KOMBINASI EKSTRAK KULIT MANGGIS DAN DFDBBX TERHADAP JUMLAH OSTEOKLAS DAN FIBROBLAS 7 HARI PASCA EKSTRAKSI (Cavia cobaya). Thesis thesis, Universitas Airlangga.

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Abstract

Background : Preservation of the alveolar bone at the time of extraction is crucial on implant placement. Combination of mangosteen peel extracts with DFDBBX in tooth extraction wounds expected to reduce osteoclast cell proliferation and accelerate the fibroblast proliferation. Purpose : The purpose of this study was to know the effect of combination induction of mangosteen peel extract and DFDBBX at socket preservation. Material and Methods : 28 Cavia cobaya were divided into 4 groups. Extraction to the lower left incisor of Cavia cobaya was done. On the tooth socket, Group I was given PEG, Group II was given DFDBBX and PEG, Group III was given mangosteen peel extract and PEG, Group IV was given mangosteen peel extract, DFDBBX and PEG. After 7days Cavia cobaya was executed and the mandible was cutted for decalcification with EDTA. Preparations for histologic examination wa done. The number of osteoclast and fibroblast was counted by light microscope, 400 times magnification. Calculation data of osteoclast and fibroblast was performed by one-way ANOVA test and Tukey HSD test. Results : The combination of mangosteen extract, DFDBBX and PEG has the most ability to reduce osteoclast and accelerate fibroblast proliferation Conclusion : Combination of mangosteen extract, DFDBBX and PEG can reduce osteoclast and accelerate fibroblast proliferation

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