NADIA WIRANTARI, NIM011218046304 (2017) photoaging, produk metabolit amniotic membrane stem cell, intrinsik, ekstrinsik. Thesis thesis, Universitas Airlangga.

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Abstract

Prolonged use of diaper may alter skin barrier function, due to exposure to irritants from feces and urine, concurrent mechanical friction and occlusion, thus render the skin prone to inflammation and infection. Measurement of skin pH and TEWL may be used to document skin barrier function, especially in tropical country such as Indonesia, and the difference between diapered and nondiapered skin. Purpose: to compare the difference of pH and TEWL value between baby’s diapered and nondiapered skin. Methods: in this cross sectional study, 43 healthy babies aged 1 to 6 months were measured using pHmeter Hanna HI99181 and Tewameter TM300 on diapered and nondiapered skin. pH and TEWL values were documented and compared. Results: the mean pH value of diapered area is 6,11±0,72 (95% CI, 4,88- 8,02) and nondiapered area is 5,91±0,69 (95% CI, 4,53-7,69), with significant difference (p= 0,005). The mean TEWL value of diapered skin is 22,96 ± 12,42 g/m2/h (95% CI, 10,80 - 58,30) and nondiapered skin is 18,49 ± 9,29 g/m2/h (95% CI, 10,60 - 51,80), with significant difference (p=0,006). Conclusions: pH and TEWL values increase significantly on diapered skin compared to nondiapered skin, revealing impaired barrier function on diapered skin, despite no pathological skin changes.

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