LINA MARTA RAMADANI, 051211133015 (2016) OPTIMASI FORMULA TABLET PARASETAMOL DENGAN SURFAKTAN SODIUM LAURIL SULFAT DAN PENGIKAT PVP K-30 DENGAN METODE GRANULASI BASAH. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The aim of this study was to determine the effect of sodium lauryl sulfate 0,5% and 2,5% as a surfactant and PVP K-30 0,5% and 5% as a binder on the physical quality (hardness, friability, disintegration time) and dissolution of paracetamol tablets made by wet granulation. Tablets were made containing 500 mg paracetamol and compressed at 1 ton by hydraulic press. Tablets were evaluated for hardness, friability, disintegration time and dissolution. The result showed that mechanical strength of the tablet containing PVP K-30 5% was better than the tablet containing PVP K-30 0,5%. The friability of all formulas were more than 1%, disintegration time were less 15 minutes, and percent dissolved within 30 minutes were more than 80%, except for first formula.

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