ZAKARIA RAHMAN, 051311133188 (2017) PENGARUH KADAR POLIMER NATRIUM ALGINAT TERHADAP EFEKTIVITAS IN VIVO MIKROSFER ERITROPOETIN-ALGINAT (Metode Gelasi Ionotropik dengan Teknik Aerosolisasi). Skripsi thesis, Universitas Airlangga.

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Abstract

Erythropoietin is used for anemia therapy. Nowadays, it is known that erythropoietin has neuroprotectant activity on animal with Parkinson’s disease. Erythropoietin which administered by narrow frequency can reduce patient’s comfort. In this study, erythropoietin alginate microspheres were made to reduce the administration frequency of erythropoietin and to determine the effect of polymer concentration on its in vivo effectiveness. Eritropetin-alginate microsphere were made by ionotropic gelation method with aerosolization technique using Na-alginate as polymer and CaCl2 as cross-linker. To increase microsphere’s stability during storage, microsphere formed were dried using Freeze-Dryer and maltodextrin 5% was added to protect microsphere during lyophilization. The result of this study indicated that the increasing consentration of polymer had no significant effect on its in vivo effectiveness, but Erythropoietin alginate microsphere that containing 5000 unit Erythropoietin can increase percentage of reticulocyte better than control positive group.

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