NIRMALASARI, 051311133056 (2017) KARAKTERISASI KOMPLEKS INKLUSI ASAM p-METOKSISINAMAT (APMS) HIDROKSIPROPIL β-SIKLODEKSTRIN YANG DIPREPARASI DENGAN METODE MICROWAVE IRRADIATION. Skripsi thesis, Universitas Airlangga.

Preview	Text (ABSTRAK) FF F 39-17 Nir k Abstrak.pdf Download (49kB) | Preview
	Text (FULLTEXT) FF F 39-17 Nir k Sec.pdf Restricted to Registered users only until 2 November 2020. Download (1MB) | Request a copy

Abstract

The inclusion complex between p-methoxcycinnamic acid (APMS) and hydroxypropyl-β-cyclodextrin (HPβCD) prepared in this research is one of the answer to the low aqueous solubility of APMS. This research is aimed to characterize the inclusion complex of APMS-HPβCD through analysis by infrared spectrophotometry, Differential Thermal Analysis (DTA), and X-ray diffraction. APMS-HPβCD inclusion complex is prepared by microwave irradiation in 1:1 molar ratio. Then the characteristics of the complex are compared with APMS and HPβCD in each single compound, and its physical mixture. The characterization analysis showed that the inclusion complex infrared spectra differ from that of each single compound and its physical mixture. The band of carboxylic C=O and O-H is disappeared in inclusion complex spectra, while the band of carboxylic C=O in physical mixture spectra is still detected but appears in lower intensity. DTA analysis of both inclusion complex and physical mixture produce a single endothermic peak with melting point lower than that of its single compound. Otherwise, the X-ray diffraction studies of physical mixture show the superimposition of the each single compound diffractogram. While the diffractogram of inclusion complex demonstrated that the crystallinity of APMS is decreased but several crystalline peaks still exist. According to those results above, it can be concluded that the formation of inclusion complex by microwave irradiation method in this research hasn’t done completely yet due to the still existing peak belonged to APMS.

Actions (login required)

View Item