NADIA PRAMASARI, 051311133078 (2017) PENGARUH HIDROKSIPROPIL-β- SIKLODEKSTRIN (HPβCD) SEBAGAI SENYAWA PEMBENTUK KOMPLEKS INKLUSI TERHADAP KELARUTAN ASAM para METOKSISINAMAT (APMS) PADA BERBAGAI pH. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

para Methoxycinnamic Acid (pMCA) is the hydrolysis compound from ethyl-p-methoxycinnamate (EPMC) which considered as the largest amount of compound in kencur (Kaempferia galanga). pMCA has analgesic and antiinflammation activity. However, it has poor solubility on water. Thus, inclusion complex formation can be performed to increase the pMCA solubility. Inclusion complex is one of the complex system formed by the existence of guest molecule trapped in the host molecule. Hydroxypropyl-β- cyclodextrin (HPβCD) is a host with an ability to form inclusion complex. pMCA is considered as a weak acid with pKa value of 4,04. Its solubility is affected by pH because the change of pH can cause the amount change of ionic and non-ionic state. In the formation of inclusion complex, non-ionic state will enter into HPβCD easily and form a more stable complex than ionic state. The result of this study indicated that the addition of HPβCD 0,01 M had a positive effect to increase the solubility of pMCA at pH 2,0; 3,0; 4,0; 5,0; 6,0 and 7,0. The increase of pH led to percentage increase of pMCA solubility with 0.01 M HPβCD becoming smaller. However, the pMCA solubility increase at pH 2.0 was not greater than pH 3.0. Based on t-test, there was difference between pMCA solubility in various pH of buffer solution without and with HPβCD 0,01 M. It is suggested to use buffer component which has no effect to HPβCD structure in subsequent study.

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