NI PUTU MAYTRIE, 051311133157 (2017) PENGARUH KADAR KOPOLIMER ASAM METAKRILAT TIPE L SEBAGAI MATRIKS MIKROPARTIKEL TERHADAP EFISIENSI PENJEBAKAN Lactobacillus casei (Metode Spray Drying Suhu Inlet 120 OC). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Microparticles are type of drug delivery systems where the particle size ranges from 1-1000 μm. It is suitable for sensitive substances such as probiotic bacteria that are not resistant to acidic environments and high temperatures. Metacrylic acid copolimer L type was used as a matrix polymer with the objective of enhancing survival of the probiotic bacteria and keeping them during exposure to the adverse conditions of the gastro-intestinal tract. The aim of this study was to determine effect of Metacrylic acid copolimer L type concentration with Lactobacillus casei encapsulation efficiency in microparticle by spray drying method. Lactobacillus casei was made into microparticle by spray drying method in 120 oC inlet temperature with three different concentration of Copolimer metacrylic acid L type. Three different formula were named formula I, formula II, formula III with 0,5%; 0,75%; and 1% concentration of Metacrylic acid copolimer L type. Moisture content was decreased with increasing Metacrylic acid copolimer L type concentration. The largest particle size of microparticle was obtained by formula III. Encapsulation efficiency of microparticle increased with increasing Metacrylic acid copolimer L type concentration (p<0,05). The result showed that the best encapsulation efficiency was obtained by formula III which contain Copolimer metacrylic acid tipe L concentration 1% with a percentage of 92,46 ± 0,17% .

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