Rahayu Nofita Sari, NIM011311133022 (2017) KORELASI ANTARA KADAR KOLESTEROL HDL DENGAN DERAJAT FUNGSIONAL BERDASARKAN NIHSS PENDERITA STROKE TROMBOTIK AKUT DI RSUD DR. SOETOMO SURABAYA. Skripsi thesis, Universitas Airlangga.

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Abstract

Stroke is the third highest cause of death in developed countries, as well as the leading cause of disability. One of the risk factor of stroke is dyslipidemia, which is defined as unbalance serum cholesterol levels in the blood. Low level of High Density Lipoprotein (HDL) cholesterol are well recognized to be closely associated with increased risk of ischaemic stroke. The relationship between serum lipid levels and the incidence of infarction stroke still remains controversional. Lipid serum are thought to interact with the pathogenesis of stroke through an atherosclerosis mechanism. Lower HDL cholesterol level has significant effects on the outcome of thrombotic stroke patients. The goal of this study is to proof a correlation between HDL cholesterol and functional scale measured by NIHSS in acute trhombotic stroke patients. Forty patients with acute trhombotic atroke that complete inclusion and exclusion criteria were admitted in neurology ward Dr.Soetomo Hospital Surabaya in period August 2016 until October 2016. Those patients have been examined for functional scale by NIHSS and keeping of the laboratory result trough medical record of the patients. The mean of age was 58,13 ± 10,41years old. Twenty-one subjects were men and Nine-teen were women with eleven people are smoker and twenty—nine are non smoker. Mean of HDL cholesterol level was 38,02 ± 7,69 mg/dl. Mean of NIHSS was 5,92 ± 4,88. There is negative correlation between HDL cholesterol level and functional scale measured by NIHSS in acute thrombotic stroke patients. This result is statistically significant (r = 0,391 dan p = 0,013). There is negative correlation between HDL cholesterol level and functional scale measured by NIHSS in acute trhombotic stroke patients.

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