HIMMAH AYU MUHIMMAH, 051111128 (2017) POTENSI ANTIDEPRESAN SSRI UNTUK MENGATASI ADIKSI MORFIN. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Addiction is a brain disorder caused by chronic exposure of an addictive substance that triggered the release of dopamine neurotransmitter in mesocorticolimbic dopaminergic circuit that produced the reward effect. The controlled use of opioid drug may develop into compulsive drug use and addiction. Chronic opioid treatment tends to reduce basal 5-HT levels and cause the 5-HT supersensitive synapse. This research aimed to investigate the effect of SSRI antidepressants fluoxetine and paroxetine on the morphine addiction at acquisition stage. 3-4 weeks old male Balb/C mice were used. The effect of SSRI antidepressants fluoxetine and paroxetine on morphine addiction at acquisition stage was observed using conditioned place preference paradigm. The results showed that fluoxetine and paroxetine exhibited different effect on morphine addiction at acquisition stage. Morphine 10 mg/kg significantly increased the CPP score of mice. Fluoxetine 5 mg/kg and 10 mg/kg did not alter the CPP score of morphine injected mice. However, paroxetine 5 mg/kg and 10 mg/kg significantly decrease the CPP score of morphine injected mice. Therefore, it is suggested that paroxetine may potentialy attenuate the rewarding effect of morphine at acquisition stage.

Item Type:	Thesis (Skripsi)
Additional Information:	KKB KK-2 FF.FK. 59-17 Muh p
Uncontrolled Keywords:	addiction, morphine, antidepressant SSRI, fluoxetine, paroxetine, conditioned place preference
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	05. Fakultas Farmasi > Farmasi Klinis
Creators:	Creators NIM HIMMAH AYU MUHIMMAH, 051111128 UNSPECIFIED
Contributors:	Contribution Name NIDN / NIDK Thesis advisor Mahardian Rahmadi, M.Sc., Ph.D., Apt. UNSPECIFIED Thesis advisor Toetik Aryani, Dra., M.Si., Apt. UNSPECIFIED
Depositing User:	Tatik Poedjijarti
Date Deposited:	13 Nov 2017 19:30
Last Modified:	13 Nov 2017 19:30
URI:	http://repository.unair.ac.id/id/eprint/66453
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