HANDITYA PUTRI TRININGRUM, 061324153001 (2017) EFEK PROTEKTIF VITAMIN E TERHADAP JUMLAH SEL LEYDIG DAN KADAR TESTOSTERON MENCIT (Mus musculus) YANG DIPAPAR TCDD (2, 3, 7, 8 -Tetrachloro-dibenzo-p-dioxin) PENELITIAN EKSPERIMENTAL LABORATORIS. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The aims of this study is to determine the protective effect of vitamin E as an antioxidant that capable to maintain the number of Leydig cells and testosterone levels of mice exposed by TCDD. This study was a laboratory experimental study, with five threatment group and six replications of male (Mus musculus) mice which administered vitamin E by orally at different doses (P1 (11mg), P2 (20mg), and P3 (37mg)) Beginning as protectan. Four hours after giving pf vitamin E, they were exposuring of TCDD with doses 100ng / oral. After all treatment is given, the next step is to making preparations with HE staining to calculate the number of Leydig cell and ELISA test to calculate testosterone levels in blood serum mice. The results of the protective effect of vitamin E showed that there was a significant difference between K+ and K-. On the results of testosterone levels showed in the K group is significantly different from the K+ group. In the K+. The conclusion is the protective effect of vitamin E were exposed by TCDD at 37 mg doses.

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