ANI RIANI HASANA, 051514153008 (2018) HUBUNGAN KUANTITATIF STRUKTUR-AKTIVITAS ANALGESIK SENYAWA 2-BENZAMIDO-N-BENZOILBENZAMIDA DAN TURUNANNYA PADA MENCIT (Mus musculus). Thesis thesis, Universitas Airlangga.

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Abstract

Four analogs of 2-benzamido-N-benzoylbenzamide; 2-(2-chlorobenzamido)-N- (2-chlorobenzoyl)benzamide; 2-(3-chlorobenzamido)-N-(3-chlorobenzoyl)benzamide; and 2-(4-chlorobenzamido)-N-(4-chlorobenzoyl)benzamide have been designed, synthesized, and structurally were confirmed by UV-Vis Spectrophotometry, 1H-NMR, 13C-NMR, FT-IR and MS Spectroscopic methods. All compounds were evaluated by for their analgesic activity in vivo by acetic acid induced writhing test on mice (Mus musculus). The test showed that 2-benzamido-N-benzoylbenzamide; 2-(3- chlorobenzamido)-N-(3-chlorobenzoyl)benzamide; and 2-(4-chlorobenzamido)-N-(4- chlorobenzoyl)benzamide possessed higher analgesic activity compared mefenamic acid. 2-(2-chlorobenzamido)-N-(2-chlorobenzoyl)benzamide dose 50 mg/kg body weight has higher analgesic activity compared to mefenamic acid dose 50 mg/kg body weight, QSAR studies showed the best correlation belongs to relationship between lipophilic parameter (ClogP) and analgesic study.

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