Mulia Rahmah, drg, 021518036318 (2018) EKSPRESI MMP-1 DAN TGF-β1 SETELAH APLIKASI DENTIN BONDING BERBASIS HEMA. Thesis thesis, Universitas Airlangga.

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Abstract

Dentin bonding is the material to attach the composite resin to dentine. The main composition is 2-hydroxyethyl methacrilate (HEMA). After polimerization, occured residual monomers which diffuse from dentinal tubuli to pulp can affected odontoblast. Objective: To analyze MMP-1 and TGF-β1 expression on odontoblast of complex dentin pulp of wistar rat tooth which was treated with dentin bonding HEMA dan HEMA murni. Methods: Maxillary first molar toot wistar rat was only bur prepared for 3 days (group 1), then HEMA 10 % was aplicated for 3 days (group 2). Dentin bonding HEMA was aplicated and polimerization light cured for 3 days (group 3). After aplication HEMA and dentin bonding HEMA the tooth was filled with RMGIC. The rat was sacrifised and maxillary resection on the define day for immunohistochemistry evaluation. Result: Expression MMP-1 on dentin bonding HEMA were lower than HEMA, expression TGF-β1 on dentin bonding HEMA were higher than HEMA. Conclusion : There were significant differences on expression MMP-1 dan TGF- β1 between dentin bonding HEMA and HEMA

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