DANANG SAKSONO, NIM011180115 (2018) PERBANDINGAN EKSPRESI PROTEIN PEROXIREDOXIN-2 ANTARA PTERIGIUM PRIMER DENGAN PTERIGIUM REKUREN (Studi Observasional Analitik Cross Sectional pada Pasien Instalasi Rawat Jalan Rumah Sakit Mata Masyarakat Jawa Timur). Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Purpose: To determine the role of peroxiredoxin-2 protein in the recurrence of pterygium. Methods: Twenty seven primary pterygiums, eighteen recurrent pterygiums, and two normal bulbar conjunctivae obtained in this study. Formalin-fixed, paraffinembedded tissues were analyzed by immunohistochemistry methods with peroxiredoxin-2 primary antibody. Results: The statistical tests results showed that there was no significant difference in terms of age and sex between primary and recurrent pterygium groups (p=0,281; p=0,226). The level of peroxiredoxin-2 expression on the primary pterygium (class 0: vacant, class 1: 4, class 2: 20, class 3: 3) did not differ significantly with recurrent pterygium (class 0: vacant, class 1: 2, class 2: 11, class 3: 5), the Mann Whitney Test results show p=0,227 ( p>0,05). Conclusion: The results of this study indicate that peroxiredoxin-2 is not involved predominantly in pterygium recurrence. There are other mechanisms that are more influential in pterygium recurrence.

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