Noor, Meitria Syahadatina and Bakhriansyah, H.M and Widjiati and Santoso, Budi (2012) Effect of Nicotine on Serum Malondialdehide (MDA) in Rattus Novergicus. Proceeding International Seminar : Strategy To Manage Bio-Eco-Health System for Stabilizing Animal Health & Productivity to Support Public Health. pp. 308-310. ISSN 978-602-8967-69-3

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Abstract

Indonesia was the third tobacco consumption country after China dan India. Girls who smoked in Indonesia was 4% dan women was 4,5%. Tobacco in cigarette had bad effects to health, and the major component of it was nicotine as prooxidant. This research was to know the effect of nicotine to serum MDA as indicator of oxidative stress. Design of this research was experimental with post test only control group design. Subjects consisted of 4 groups (40 rats) that were chosen homogeny and random. The groups were control (NaCMC), treatment dan groups that were injected by nicotine subcutaneous for 7 days. The doses were 21 mg/kgBW, 42 mg/kgBW dan 84 mg/kgBW. The observation was calculating MDA. The result of one way Anova was significant differences among all of the groups (p < 0.05). That analysis was continued by Tuckey HSD test. It showed significant difTerences between control and all of treatment groups (p < 0.05), 21 and 42 mg/kgBW with 84 mg/kgBW (p < 0.05), and 84 mg/kgBW with the other groups. The conclusion was nicotine could increase serum MDA in Rattus novergicus

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